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Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly

Identifieur interne : 002129 ( Main/Exploration ); précédent : 002128; suivant : 002130

Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly

Auteurs : M. Ramos-Casals [Espagne] ; M. García-Carrasco [Espagne] ; M P Brito [Espagne] ; A. L Pez-Soto [Espagne] ; J. Font [Espagne]

Source :

RBID : ISTEX:A57F9B6A9092AB7AE3FF778E887B5BE308357FCC

English descriptors

Abstract

The immune system undergoes continuousmorphologic and functionalchanges throughoutthe years, and it is now believed that the immune response has its peak function in puberty and gradually decreases with age (immunosenescence). Recent studies in healthy octogenarian patients suggest that the immune system, instead of suffering a generalized deterioration, undergoes a remodelling/readjustment of its major functions. Increase in two contrasting phenomena coexist in immunosenescence: on the one hand, a decrease in the capacity of the immune response and, on the other hand autoantibodyproduction.The possibleconsequencesof this progressive‘ageing’ of the immune system are the increasein autoimmune phenomena, incidenceof neoplasiaand predisposition to infections. The study of autoimmune manifestations in elderly populations should be considered a priority for future medical research because of increasing life expectancy, especially in developed countries. This review analyses the main immune disorders associated with immunosenescence, the prevalence and clinical significance of autoantibodiesin the elderly and the clinical expression of the main autoimmune diseases in older patients.

Url:
DOI: 10.1191/0961203303lu383ed


Affiliations:


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Le document en format XML

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<term>Ageing</term>
<term>Ageing process</term>
<term>Amatory myopathies</term>
<term>Anca</term>
<term>Antibody</term>
<term>Anticardiolipin</term>
<term>Anticardiolipin antibodies</term>
<term>Antinuclear</term>
<term>Antinuclear antibodies</term>
<term>Antinuclear autoantibodies</term>
<term>Antinuclear factors</term>
<term>Antiphospholipid</term>
<term>Antiphospholipid antibodies</term>
<term>Antiphospholipid syndrome</term>
<term>Arch intern</term>
<term>Arteritis</term>
<term>Arthritis</term>
<term>Arthritis rheum</term>
<term>Articular involvement</term>
<term>Atheromatous disease</term>
<term>Atypical manifestations</term>
<term>Autoantibody</term>
<term>Autoimmune</term>
<term>Autoimmune diseases</term>
<term>Autoimmune manifestations</term>
<term>Autoimmune phenomena</term>
<term>Autoimmunity</term>
<term>Biopsy</term>
<term>Bone marrow</term>
<term>Breast cancer</term>
<term>Cell antibodies</term>
<term>Cell proliferation</term>
<term>Cervera</term>
<term>Classi cation</term>
<term>Clin</term>
<term>Clin immunol immunopathol</term>
<term>Clinical course</term>
<term>Clinical expression</term>
<term>Clinical features</term>
<term>Clinical presentation</term>
<term>Clinical signi cance</term>
<term>Clinical study</term>
<term>Corticosteroid</term>
<term>Corticosteroid therapy</term>
<term>Cutaneous involvement</term>
<term>Delay diagnosis</term>
<term>Dermatomyositis</term>
<term>Diabetes mellitus</term>
<term>Different series</term>
<term>Diseas</term>
<term>Disease activity</term>
<term>Disease duration</term>
<term>Disease onset</term>
<term>Diverse symptomatology</term>
<term>Early onset</term>
<term>Elderly</term>
<term>Elderly patients</term>
<term>Elderly people</term>
<term>Elderly subjects</term>
<term>Epidemiological study</term>
<term>Erythematosus</term>
<term>Erythrocyte sedimentation rate</term>
<term>General population</term>
<term>Generalized deterioration</term>
<term>Geriatrics</term>
<term>Giant cell</term>
<term>Giant cell arteritis</term>
<term>Healthy centenarians</term>
<term>High frequency</term>
<term>High incidence</term>
<term>High mortality rates</term>
<term>High prevalence</term>
<term>High risk</term>
<term>Higher frequency</term>
<term>Higher rates</term>
<term>Hunder</term>
<term>Immune</term>
<term>Immune complexes</term>
<term>Immune functions</term>
<term>Immune response</term>
<term>Immune responses</term>
<term>Immune system</term>
<term>Immunol</term>
<term>Immunologic</term>
<term>Immunologic markers</term>
<term>Immunological characteristics</term>
<term>Independent risk factor</term>
<term>Infectious diseases</term>
<term>Initial dose</term>
<term>Insidious presentation</term>
<term>Ischemic stroke</term>
<term>Laboratory parameters</term>
<term>Late onset</term>
<term>Longitudinal analysis</term>
<term>Lower frequency</term>
<term>Lupus</term>
<term>Lupus anticoagulant</term>
<term>Lupus erythematosus</term>
<term>Lymphocyte</term>
<term>Major prevalences</term>
<term>Malignancy</term>
<term>Mech</term>
<term>Mech ageing</term>
<term>Ndings</term>
<term>Nonautoimmune mice</term>
<term>Normal cells</term>
<term>Normal subjects</term>
<term>Nuclear staining</term>
<term>Nucleosomes</term>
<term>Older group</term>
<term>Older patients</term>
<term>Olmsted county</term>
<term>Other autoantibodies</term>
<term>Other studies</term>
<term>Parotid saliva</term>
<term>Physical examination</term>
<term>Polyarteritis nodosa</term>
<term>Polymyalgia</term>
<term>Polymyalgia rheumatica</term>
<term>Polymyositis</term>
<term>Poor prognosis</term>
<term>Prevalence</term>
<term>Primary syndrome</term>
<term>Prospective study</term>
<term>Rachima maoz</term>
<term>Recent study</term>
<term>Rheum</term>
<term>Rheumatic disease clinics</term>
<term>Rheumatic diseases</term>
<term>Rheumatica</term>
<term>Rheumatoid</term>
<term>Rheumatoid arthritis</term>
<term>Rheumatoid factor</term>
<term>Rheumatoid factors</term>
<term>Rheumatol</term>
<term>Risk factor</term>
<term>Salivary</term>
<term>Salvarani</term>
<term>Semin arthritis rheum</term>
<term>Serological characteristics</term>
<term>Serum levels</term>
<term>Several studies</term>
<term>Sicca syndrome</term>
<term>Side effects</term>
<term>Signi</term>
<term>Signi cance</term>
<term>Signi cantly</term>
<term>Similar results</term>
<term>Similar study</term>
<term>Spanish edition</term>
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<term>Steroid treatment</term>
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<term>Systemic</term>
<term>Systemic lupus erythematosus</term>
<term>Systemic sclerosis</term>
<term>Systemic symptoms</term>
<term>Temporal</term>
<term>Temporal arteries</term>
<term>Temporal arteritis</term>
<term>Temporal artery</term>
<term>Temporal artery biopsy</term>
<term>Thrombosis</term>
<term>Unknown origin</term>
<term>Utoim</term>
<term>Venous thromboembolism</term>
<term>Visual loss</term>
<term>Visual symptoms</term>
<term>Weight loss</term>
<term>Xerostomia</term>
<term>Xerostomic symptoms</term>
<term>Young adults</term>
<term>Young women</term>
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<div type="abstract" xml:lang="en">The immune system undergoes continuousmorphologic and functionalchanges throughoutthe years, and it is now believed that the immune response has its peak function in puberty and gradually decreases with age (immunosenescence). Recent studies in healthy octogenarian patients suggest that the immune system, instead of suffering a generalized deterioration, undergoes a remodelling/readjustment of its major functions. Increase in two contrasting phenomena coexist in immunosenescence: on the one hand, a decrease in the capacity of the immune response and, on the other hand autoantibodyproduction.The possibleconsequencesof this progressive‘ageing’ of the immune system are the increasein autoimmune phenomena, incidenceof neoplasiaand predisposition to infections. The study of autoimmune manifestations in elderly populations should be considered a priority for future medical research because of increasing life expectancy, especially in developed countries. This review analyses the main immune disorders associated with immunosenescence, the prevalence and clinical significance of autoantibodiesin the elderly and the clinical expression of the main autoimmune diseases in older patients.</div>
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